PozNews - HIV News - STD News: Chlamydia pneumoniae IgG and IgA antibody titers and prognosis in patients with coronary heart disease: results from the CLARICOR trial

Chlamydia pneumoniae IgG and IgA antibody titers and prognosis in patients with
coronary heart disease: results from the CLARICOR trial
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MedWorm on 12 March, 2010 06:32:52
 
Abstract: The association observed between coronary heart disease (CHD) and
Chlamydia (Chlamydophila) pneumoniae antibodies prompted, during the 1990s,
several primary and secondary prevention trials with various antibiotics. In our
CLARICOR trial, a randomized placebo-controlled trial in 4372 patients with
stable CHD, a brief clarithromycin regimen was followed, unexpectedly, by
increased long-term mortality. We now compare C. pneumoniae antibody levels at
entry with population levels, with the patients' individual histories, and with
their subsequent outcomes. IgG antibody levels were somewhat raised, but
elevated IgA and IgG titers were unrelated to entry data (including prior acute
myocardial infarction), except for an association with smoking and with not
using statins. Hazards of mor...
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