PozNews - HIV News - STD News: Chlamydia pneumoniae-induced memory CD4+ T cell activation in human peripheral blood correlates with distinct antibody response patterns.

Chlamydia pneumoniae-induced memory CD4+ T cell activation in human peripheral
blood correlates with distinct antibody response patterns.
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MedWorm on 09 March, 2010 02:00:00
 
Authors: Bunk S, Schaffert H, Schmid B, Goletz C, Zeller S, Borisova M, Kern F,
Rupp J, Hermann C     Chlamydia pneumoniae is a frequent pathogen of the
respiratory tract and persistent infections with this obligate intracellular
bacterium have been associated with different severe sequelae. Although T cell
activation during acute C. pneumoniae infections has been described, little is
known about the frequency and role of C. pneumoniae-specific memory T cells that
reside in the human body after resolved infection. In the present study, C.
pneumoniae-induced T cell responses in peripheral blood mononuclear cells of 56
healthy volunteers were analyzed and compared to the donor's serum antibody
reactivity towards whole C. pneumoniae as well as recombinant C. pneumoniae
antigens. Following sho...