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A Loss-of-Function Screen Reveals Ras- and Raf-Independent MEK-ERK Signaling
During Chlamydia trachomatis Infection.
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MedWorm on 18 March, 2010 08:24:03
 
Authors: Gurumurthy RK, Mäurer AP, Machuy N, Hess S, Pleissner KP, Schuchhardt
J, Rudel T, Meyer TF     Chlamydiae are obligate intracellular bacterial
pathogens that have a major effect on human health. Because of their intimate
association with their host, chlamydiae depend on various host cell functions
for their survival. Here, we present an RNA-interference-based screen in human
epithelial cells that identified 59 host factors that either positively or
negatively influenced the replication of Chlamydia trachomatis (Ctr). Two
factors, K-Ras and Raf-1, which are members of the canonical Ras-Raf-MEK
(mitogen-activated or extracellular signal-regulated protein kinase kinase)-ERK
(extracellular signal-regulated kinase) pathway, were identified as central
components of signaling networ...