PozNews - HIV News - STD News: A link between neutrophils and chronic disease manifestations of Chlamydia muridarum urogenital infection of mice

A link between neutrophils and chronic disease manifestations of Chlamydia
muridarum urogenital infection of mice
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MedWorm on 28 March, 2010 02:00:00
 
Vigorous acute inflammatory responses accompany Chlamydia muridarum infections
in mice and are positively correlated with adverse urogenital and respiratory
tract infection outcomes in the mouse model. Thus, we tested the hypothesis that
neutrophils induce an acute inflammatory insult that, in the repair phase, leads
to the chronic sequelae of hydrosalpinx [ndash] a surrogate marker of
infertility in the mouse model. To this end, we induced neutropenia in mice
using a neutrophil-depleting monoclonal antibody during acute phases of C.
muridarum urogenital infection only (days 2[ndash]21 postinfection). To prove
induced neutropenia, peripheral blood was monitored for neutrophils during the
treatment regimen. Neutropenic mice had a similar infection course as control
mice, but had significant...